Intratumoral and intraperitoneal administration of B28Bn(6,four) significantly suppressed the growth of prostate tumors in a mouse design with out any evident side outcomes (Determine 5)
As predicted, Bn(6,4) substantially improved the cytotoxicity of B28 towards DU145 and Pc-3 cells at two, mM. Conversely, the B28-Bn(two,) conjugate, B28Bn(2,) missing the C-terminal receptor-binding fragment of bombesin, exhibited…