Function by Silverman and collaborators also supports that Leishmania exosomes modulate the innate immune system and functions this kind of as IFN-c-induced IL-eight and TNF-a in monocytes, as well as expression of co-stimulatory molecules by maturated dendritic cells
GP63 is a zinc-dependent metalloprotease that exists abundantly on the surface of promastigotes, connected via a GPI-anchor . Cleavage of the GPI anchor via phospholipase C triggers constant shedding of…