Product Name: CHIR-99021 (CT99021)
Subtitle: GSK-3 inhibitor, Cell-permeable, ATP-competitive
Biological Activity: Biological Activity of CHIR-99021 (CT99021)Potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3) (IC50 values are 6.7 and 10 nM for GSK-3β and GSK-3α respectively). Exhibits >500-fold selectivity for GSK-3 over closely
SMLES: CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
CAS NO: 23109-05-9
Standard In CHIKey: Apoptosis inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C22H18Cl2N8
M.Wt: 465.34
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/257/1/479
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 20 mM in DMSO
Storage: Store at -20℃
Purity: >98%
Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile