Product Name: Cyclopamine
Subtitle: Hedgehog (Hh) signaling Inhibitor
Biological Activity: Biological Activity of Cyclopamine Inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anticancer and teratogenic in vivo. Depletes stem-like cancer cells in glioblas
SMLES: C[C@@H]1CN[C@H]2[C@@H](C)[C@@]3(CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C)O[C@@H]2C1
CAS NO: 1093403-33-8
Standard In CHIKey: QASFUMOKHFSJGL-LAFRSMQTSA-NNampt inhibitors
Standard InChI: InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
Typrof Compound: Alkaloids
Appearance: Powder
Formula: C27H41NO2
M.Wt: 411.6
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/259/2/738
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 5 mM in ethanol
Storage: Desiccate at -20℃
Purity: ≥98%
Chemical Name: (2R,3S,3R,3aS,6S,6aS,6bS,7aR,11aS,11bR)-1,2,3,3a,4,4,5,6,6,6a,6b,7,7,7a,8,11,11a,11b-Octadecahydro-3,6,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2(3H)-furo[3,2-b]pyridin]-3-ol