Product Name: Dacomitinib (PF299804, PF299)
Subtitle: HER inhibitor
Biological Activity: Biological Activity of Dacomitinib (PF299804, PF299)Description PF-299804 is a potent, irreversible inhibitor of ErbB for EGFR with IC50 of 6 nM. Targets ErbB1 ErbB2 ErbB4 IC50 6 nM 45.7 nM 73.7 nM
SMLES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)C=CCN4CCCCC4
CAS NO: 1523406-39-4
Standard In CHIKey: Neurological Disease inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C24H25ClFN5O2
M.Wt: 469.94
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/254/3/864
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: (E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide