Product Name: Foretinib (GSK1363089)
Subtitle: VEGF and HGF receptor inhibitor
Biological Activity: Biological Activity of Foretinib (GSK1363089)Description Foretinib is an ATP-competitive inhibitor of HGFR and VEGFR with IC50 values of 0.4 nM, 0.9 nM, 1.1 nM, 2.8 nM and 3 nM for Met, KDR, Tie-2, VEGFR3/FLT4 and RON , respectively. Targets Met
SMLES: COc1cc2c(ccnc2cc1OCCCN3CCOCC3)Oc4ccc(cc4F)NC(=O)C5(CC5)C(=O)Nc6ccc(cc6)F
CAS NO: 1219168-18-9
Standard In CHIKey: Raf inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C34H34F2N4O6
M.Wt: 632.65
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/259/1/302
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: Foretinib