Product Name: GDC-0152
Subtitle: IAP antagonist,potent amd samll-molecule
Biological Activity: Biological Activity of GDC-0152Description GDC-0152 is a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins with Ki values of 28, 14, 17 and 43 nM for XIAP, ML-IAP, cIAP1 and cIAP2, respectively. Targets XIAP ML-IAP cIAP1
SMLES: CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC
CAS NO: 937272-79-2
Standard In CHIKey: PARP inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C25H34N6O3S
M.Wt: 498.64
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/251/1/334
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: (2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide