Product Name: Gambogic acid
Subtitle: Caspase activator and apoptosis inducer
Biological Activity: Biological Activity of Gambogic acid Apoptosis inducer in several tumor cell lines including T47D cells. Activates caspases (EC50 values are 0.78 – 1.64 μM) and competitively inhibits antiapoptotic Bcl-2 family proteins (IC50 values are 1.47, 1.21, 2
SMLES: CC(C)=CCC[C@@]1(C)Oc2c(CC=C(C)C)c3O[C@@]45C6CC(C=C4C(=O)c3c(O)c2C=C1)C(=O)C5(CC=C(C)C(O)=O)OC6(C)C
CAS NO: 1629268-00-3
Standard In CHIKey: GEZHEQNLKAOMCA-PLUQQRNKSA-NHBV inhibitors
Standard InChI: InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23?,27?,36-,37?,38-
Typrof Compound: Miscellaneous
Appearance: Yellow cryst.
Formula: C38H44O8
M.Wt: 628.75
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/250/3/842
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 75 mM in DMSO and to 100 mM in ethanol
Storage: Store at -20℃
Purity: ≥98%
Chemical Name: (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid