Product Name: HLI 373
Subtitle: Hdm2 ubiquitin ligase (E3) inhibitor
Biological Activity: Biological Activity of HLI 373Inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53
SMLES: O=C(C1=C(NCCCN(C)C)C2=C(N(C)C1=N3)C=CC=C2)N(C)C3=O.Cl.Cl
CAS NO: 1269440-17-6
Standard In CHIKey: Adrenergic Receptor inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C18H23N5O2.2HCl
M.Wt: 414.33
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/251/2/484
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in water and to 10 mM in DMSO
Storage: Desiccate at RT
Purity: >98%
Chemical Name: 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride