Product Name: LY-411575
Subtitle: Gamma secretase inhibitor
Biological Activity: Biological Activity of LY-411575Description LY411575 is a potent γ-secretase inhibitor with IC50 value of 0.078 nM and 0.082 nM for membrane and cell-based, respectively. Targets γ-secretase Notch S3 cleavage IC50 0.078 nM (membrane-
SMLES: CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O
CAS NO: 442908-10-3
Standard In CHIKey: RSV inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: ted as 10 mg/ml solutions in 50% polyethylene glycol, 30% propylene glycol, 10% ethanol and diluted in 0.4% methylcellulose for dosing. Application In TgCRND8 mice, LY-411,575 decreases brain and plasma Aβ40 and Aβ42. LY-411,575 (10 mg/kg) r
M.Wt: 479.48
General Tips: for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/258/1/36
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: (2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide