Product Name: NSC 319726
Subtitle: Reactivator of mutant p53
Biological Activity: Biological Activity of NSC 319726Reactivator of mutant p53. Restores wild type p53 structure and function to the p53R175 mutant. Inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM). Also inhibits growth of xenograft tumors express
SMLES: CC(=NNC(=S)N1CCC1)C2=CC=CC=N2
CAS NO: 1610537-15-9
Standard In CHIKey: XDHBUMNIQRLHGO-LCYFTJDESA-NIRE1 inhibitors
Standard InChI: InChI=1S/C11H14N4S/c1-9(10-5-2-3-6-12-10)13-14-11(16)15-7-4-8-15/h2-3,5-6H,4,7-8H2,1H3,(H,14,16)/b13-9-
Typrof Compound:
Appearance:
Formula: C11H14N4S
M.Wt: 234.32
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/251/1/288
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Storage: Store at -20℃
Purity: >98%
Chemical Name: 1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide