Product Name: Necrostatin-1
Subtitle: RIP1 inhibitor
Biological Activity: Biological Activity of Necrostatin-1ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis
SMLES: CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
CAS NO: 827022-33-3
Standard In CHIKey: TXUWMXQFNYDOEZ-UHFFFAOYSA-NMps1 inhibitors
Standard InChI: InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
Typrof Compound:
Appearance:
Formula: C13H13N3OS
M.Wt: 259.33
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/251/1/317
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 30 mM in DMSO and to 15 mM in ethanol with gentle warming
Storage: Store at RT
Purity: >98%
Chemical Name: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone