Product Name: PD184352 (CI-1040)
Subtitle: Selective MEK inhibitor
Biological Activity: Biological Activity of PD184352 (CI-1040)Selective MEK inhibitor (Ki = 300 nM in vitro). Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol in vivo. Orally active.
SMLES: C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
CAS NO: 1260907-17-2
Standard In CHIKey: Inhibitor_Kit inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C17H14ClF2IN2O2
M.Wt: 478.67
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/255/1/154
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO and to 25 mM in ethanol
Storage: Store at +4℃
Purity: >98%
Chemical Name: 2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide