Product Name: Refametinib
Subtitle: MEK 1/ MEK 2 inhibitor
Biological Activity: Biological Activity of RefametinibDescription Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 values of 19 nM and 47 nM, respectively. Targets MEK1 MEK2 IC5
SMLES: COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)CC(CO)O)NC3=C(C=C(C=C3)I)F)F)F
CAS NO: 912445-05-7
Standard In CHIKey: Eukaryotic Initiation Factor eIF) inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C19H20F3IN2O5S
M.Wt: 572.34
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/255/2/504
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: N-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide