Product Name: U0126-EtOH
Subtitle: MEK1/2 inhibitor
Biological Activity: Biological Activity of U0126-EtOHDescription U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. Targets MEK1 MEK2 IC50 0.07 μM 0.06 μM
SMLES: CCO.C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
CAS NO: 755038-65-4
Standard In CHIKey: Stem_Cell_Signaling_Compound_Library inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C18H16N6S2.C2H6O
M.Wt: 426.56
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/255/1/128
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile;ethanol