Product Name: YO-01027 (Dibenzazepine, DBZ)
Subtitle: γ-secretase inhibitor
Biological Activity: Biological Activity of YO-01027 (Dibenzazepine, DBZ)Description YO-01027 (Dibenzazepine, DBZ) is a dipeptidic inhibitor of γ-secretase with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively. Targets APPL Notch IC50
SMLES: CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F
CAS NO: 1801747-42-1
Standard In CHIKey: Rhinovirus HRV) inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C26H23F2N3O3
M.Wt: 463.48
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/258/1/357
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide