Evels of HER1, HER2, HER3 and HER4 protein were quantified with western blot analysis (Fig. 4) and subsequent densitometry. Cells that have an elisidepsin IC50 value of #1 mM were considered sensitive to the drug. The graph represents the HER family members expression relative to elisidepsin sensitivity. A statistically significance relationship between HER3 expression levels and elisidepsin sensitivity was found (Mann-Whitney test: p = 0.0091) but not with the other members. (TIF)MedChemExpress AKT inhibitor 2 Author ContributionsConceived and designed the experiments: CT SRC JHL. Performed the experiments: CT RM. 25033180 Analyzed the data: CT JHL. Contributed reagents/ materials/analysis tools: CT RM MA SRC JHL. Wrote the paper: CT JHL.
As the world’s population ages, dementia will become a global epidemic [1]. Currently it is estimated that 5.2 million people have Alzheimer’s disease (AD) in the United States (US) alone [1]. The economic burden of dementia in the US will rise dramatically from 200 billion in 2012 to 1.1 trillion in 2050 [1]. Thus, it is a priority to identify effective prevention strategies that will combat the increasing burden dementia imposes on our population. Current evidence demonstrates physical activity is an effective prevention strategy for cognitive decline [2,3,4,5,6]. Physical activity has been identified as an effective intervention for maintaining and improving cognitive performance through promoting brain health in older adults. Directly, exercise increases brain availability of several classes of growth factors, most importantly brain-derived neurotrophic factor [7]. Brain-derivedneurotrophic factor enhances synaptic transmission, encodes long term potentiation, improves learning, promotes differentiation, neurite extension, and protects against ischemic insults and thus plays a crucial role in neuroplastic, neurotrophic, and neuroprotective POR8 web factors [7]. Brain-derived neurotropic factor also supports the health and functioning of glutamatergic neurons in the hippocampus, a brain region important in learning and memory and is the site of early deterioration in neurodegenerative diseases like AD [8]. Indirectly, exercise may promote brain health by reducing vascular risk factors such as hypertension [9], cardiovascular [10], and cerebrovascular disease [11]. As these chronic conditions are highly associated with increased body mass index (BMI) [12], regular physical activity may 1326631 also promote cognitive function in older adults by reducing adipose tissue. Increased adiposity canFat Mass Contributes to Executive Functionscause carotid-artery-wall thickening, arterial stiffness, and vascular and coronary endothelial dysfunction contributing to vascular diseases [13]. For example, these mechanisms have been linked to brain pathologies associated with vascular dementia [14], such as lacunar infarcts and white 
matter lesions [15]. Adipose tissue also secretes various bioactive metabolites (i.e., transforming growth factor b [16], tumour necrosis factor a [17], angiotensin II [18], cytokines [19], fatty acids [20]) that have been associated with dementia. Although adiposity has been linked to reduced brain health [13], the relationship between adiposity and cognitive function remains equivocal. Findings from cross sectional [21,22] and prospective cohort [23,24,25] studies report both positive and negative cognitive outcomes with increased adiposity. For example, waist circumference, waist-hip-ratio, and visceral adiposity were inversely related t.Evels of HER1, HER2, HER3 and HER4 protein were quantified with western blot analysis (Fig. 4) and subsequent densitometry. Cells that have an elisidepsin IC50 value of #1 mM were considered sensitive to the drug. The graph represents the HER family members expression relative to elisidepsin sensitivity. A statistically significance relationship between HER3 expression levels and elisidepsin sensitivity was found (Mann-Whitney test: p = 0.0091) but not with the other members. (TIF)Author ContributionsConceived and designed the experiments: CT SRC JHL. Performed the experiments: CT RM. 25033180 Analyzed the data: CT JHL. Contributed reagents/ materials/analysis tools: CT RM MA SRC JHL. Wrote the paper: CT JHL.
As the world’s population ages, dementia will become a global epidemic [1]. Currently it is estimated that 5.2 million people have Alzheimer’s disease (AD) in the United States 
(US) alone [1]. The economic burden of dementia in the US will rise dramatically from 200 billion in 2012 to 1.1 trillion in 2050 [1]. Thus, it is a priority to identify effective prevention strategies that will combat the increasing burden dementia imposes on our population. Current evidence demonstrates physical activity is an effective prevention strategy for cognitive decline [2,3,4,5,6]. Physical activity has been identified as an effective intervention for maintaining and improving cognitive performance through promoting brain health in older adults. Directly, exercise increases brain availability of several classes of growth factors, most importantly brain-derived neurotrophic factor [7]. Brain-derivedneurotrophic factor enhances synaptic transmission, encodes long term potentiation, improves learning, promotes differentiation, neurite extension, and protects against ischemic insults and thus plays a crucial role in neuroplastic, neurotrophic, and neuroprotective factors [7]. Brain-derived neurotropic factor also supports the health and functioning of glutamatergic neurons in the hippocampus, a brain region important in learning and memory and is the site of early deterioration in neurodegenerative diseases like AD [8]. Indirectly, exercise may promote brain health by reducing vascular risk factors such as hypertension [9], cardiovascular [10], and cerebrovascular disease [11]. As these chronic conditions are highly associated with increased body mass index (BMI) [12], regular physical activity may 1326631 also promote cognitive function in older adults by reducing adipose tissue. Increased adiposity canFat Mass Contributes to Executive Functionscause carotid-artery-wall thickening, arterial stiffness, and vascular and coronary endothelial dysfunction contributing to vascular diseases [13]. For example, these mechanisms have been linked to brain pathologies associated with vascular dementia [14], such as lacunar infarcts and white matter lesions [15]. Adipose tissue also secretes various bioactive metabolites (i.e., transforming growth factor b [16], tumour necrosis factor a [17], angiotensin II [18], cytokines [19], fatty acids [20]) that have been associated with dementia. Although adiposity has been linked to reduced brain health [13], the relationship between adiposity and cognitive function remains equivocal. Findings from cross sectional [21,22] and prospective cohort [23,24,25] studies report both positive and negative cognitive outcomes with increased adiposity. For example, waist circumference, waist-hip-ratio, and visceral adiposity were inversely related t.