Product Name: TFLLR-NH2Subtitle: PAR1 selective agonistBiological Activity: Biological Activity of TFLLR-NH2Peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated…
Product Name: SLIGRL-NH2Subtitle: PAR2 activatorBiological Activity: Biological Activity of SLIGRL-NH2Agonist peptide derived from the N-terminus of protease-activated receptor-2 (PAR2). Activates PAR2 (EC50 ~ 5 μM) and facilitates gastrointestinal transit in…
Product Name: A 286982Subtitle: LFA-1/ICAM-1 interaction inhibitorBiological Activity: Biological Activity of A 286982Potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated…
Product Name: BIO 1211Subtitle: α4β1 inhibitor,selective and high affinityBiological Activity: Biological Activity of BIO 1211Selective, high affinity α4β1 (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated…
Product Name: A 205804Subtitle: E-selectin/ICAM-1 expression inhibitorBiological Activity: Biological Activity of A 205804Selective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-α-induced…
Product Name: CilengitideSubtitle: Integrin inhibitor for αvβ3 and αvβ5Biological Activity: Biological Activity of CilengitidePotent and selective inhibitor of integrins αvβ3 and αvβ5 (IC50 values are 4.1 and 70 nM, respectively).…
Product Name: RN486Subtitle: Btk inhibitor,potent and selectiveBiological Activity: SMLES: CN1CCN(CC1)C2=CN=C(C=C2)NC3=CC(=CN(C3=O)C)C4=C(C(=CC=C4)N5C=CC6=CC(=CC(=C6C5=O)F)C7CC7)COCAS NO: 22033-87-0Standard In CHIKey: GPR109A inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C35H35FN6O3M.Wt: 606.69General Tips: For obtaining a higher solubility ,…
Product Name: QL47Subtitle: BTK kinase inhibitorBiological Activity: SMLES: CN(N=C1)C=C1C2=CC=C(N=CC(C=C3)=C4N(C5=CC(N(C(C=C)=O)CC6)=C6C=C5)C3=O)C4=C2CAS NO: 371935-79-4Standard In CHIKey: GPCR19 inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C27H21N5O2M.Wt: 447.49General Tips: For obtaining a higher solubility , please…
Product Name: DMXAA (Vadimezan)Subtitle: Tumnor vascular disrupting agent, apoptosis inducerBiological Activity: Biological Activity of DMXAA (Vadimezan)mSTING agonist; selective for mouse STING over human STING. Induces IFN-β and cytokine production from…
Product Name: ML161Subtitle: PAR1 inhibitorBiological Activity: Biological Activity of ML161Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human…