Product Name: PhiKan 083Subtitle: p53 stabilizerBiological Activity: Biological Activity of PhiKan 083p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction…
Product Name: NSC 146109 hydrochlorideSubtitle: Antitumor agent,p53-dependent transcription activatorBiological Activity: Biological Activity of NSC 146109 hydrochlorideCell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor…
Product Name: MIRA-1Subtitle: Restorer of wild-type p53 conformation/cellular functionBiological Activity: Biological Activity of MIRA-1Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21,…
Product Name: HLI 373Subtitle: Hdm2 ubiquitin ligase (E3) inhibitorBiological Activity: Biological Activity of HLI 373Inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent…
Product Name: Cyclic Pifithrin-α hydrobromideSubtitle: P53 inhibitorBiological Activity: Biological Activity of Cyclic Pifithrin-α hydrobromideCyclic analog of pifithrin-α, a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes…
Product Name: CP 31398 dihydrochlorideSubtitle: p53 stabilizerBiological Activity: Biological Activity of CP 31398 dihydrochloridep53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines…
Product Name: TLQP 21Subtitle: VGF-derived peptideBiological Activity: Biological Activity of TLQP 21VGF-derived peptide; spans residues 556-576 of the precursor sequence. Protects cerebellar granule cells (CGCs) from serum and potassium deprivation-induced…
Product Name: NQDI 1Subtitle: ASK1, MAP3K5 inhibitorBiological Activity: Biological Activity of NQDI 1Selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).SMLES: O=C1NC2=CC=CC3=C2C(C4=CC=CC=C4C3=O)=C1C(OCC)=OCAS…
Product Name: MelphalanSubtitle: DNA alkylating agentBiological Activity: Biological Activity of MelphalanDNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3…
Product Name: Mdivi 1Subtitle: Selective DRP1/Dnm1 inhibitor, cell-permeableBiological Activity: Biological Activity of Mdivi 1Selective inhibitor of Dnm1 GTPase (IC50 = 1 – 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division.…