Product Name: AZ 10417808Subtitle: Caspase-3 inhibitor,selective non-peptideBiological Activity: Biological Activity of AZ 10417808Selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6,…
Product Name: TW-37Subtitle: Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1Biological Activity: Biological Activity of TW-37Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). Inhibits the…
Product Name: NSC 66811Subtitle: MDM2 inhibitorBiological Activity: Biological Activity of NSC 66811Potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and…
Product Name: Nutlin-3Subtitle: MDM2 antagonist,inhibits MDM2-p53 interactionBiological Activity: Biological Activity of Nutlin-3Description Nutlin-3 is a potent and selective antagonist of Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53)…
Product Name: GDC-0152Subtitle: IAP antagonist,potent amd samll-moleculeBiological Activity: Biological Activity of GDC-0152Description GDC-0152 is a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins with Ki values of 28, 14,…
Product Name: YM155Subtitle: Survivin suppressant,apoptosis inhibitorBiological Activity: Biological Activity of YM155Description YM155 (Sepantronium Bromide) is a potent inhibitor of Survivin promoter activity with IC50 of 0.54 nM. Targets Survivin IC50…
Product Name: Birinapant (TL32711)Subtitle: Potent XIAP/cIAP1 antagonistBiological Activity: Biological Activity of Birinapant (TL32711)Description Birinapant is an antagonist of XIAP and cIAP1 with Kd value of 45 nM and
Product Name: Necrostatin-1Subtitle: RIP1 inhibitorBiological Activity: Biological Activity of Necrostatin-1ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a…
Product Name: Pomalidomide (CC-4047)Subtitle: Immunomodulator,antumor/anti-angiogenicBiological Activity: Biological Activity of Pomalidomide (CC-4047)Description Pomalidomide is an inhibitor of LPS-induced TNF-α release with IC50 of 13 nM. Targets TNF-α IC50 13 nMSMLES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCAS…
Product Name: Lenalidomide (CC-5013)Subtitle: Antineoplastic agent,inhibits angiogenesisBiological Activity: Biological Activity of Lenalidomide (CC-5013)Description Lenalidomide (CC-5013) is an inhibitor of TNF-α secretion with IC50 of 13 nM. Targets TNF-α IC50 13…