Product Name: NSC 207895 (XI-006)Subtitle: MDMX inhibitor,anti-cancer agentBiological Activity: Biological Activity of NSC 207895 (XI-006)Description NSC 207895 is an anticancer agent. Targets E3 ligase MDM2 MDMX IC50SMLES: CN1CCN(CC1)C2=CC=C(C3=NO(=C23))(=O)CAS NO: 905579-51-3Standard…
Product Name: NSC 319726Subtitle: Reactivator of mutant p53Biological Activity: Biological Activity of NSC 319726Reactivator of mutant p53. Restores wild type p53 structure and function to the p53R175 mutant. Inhibits growth…
Product Name: Pifithrin-α (PFTα)Subtitle: p53 inhibitorBiological Activity: Biological Activity of Pifithrin-α (PFTα)Inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and…
Product Name: JNJ-26854165 (Serdemetan)Subtitle: P53 activator, blocking Mdm2-p53 interactionBiological Activity: Biological Activity of JNJ-26854165 (Serdemetan)Description JNJ-26854165 (Serdemetan) is an antagonist of HDM2 ubiquitin ligase and also inducer of early apoptosis…
Product Name: Tenovin-1Subtitle: SIRT2 inhibitor, activates p53Biological Activity: Biological Activity of Tenovin-1p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21CIP/WAF1 and induces expression from an…
Product Name: RITA (NSC 652287)Subtitle: Mdm2-p53 interaction and p53 ubiquitination blockingBiological Activity: Biological Activity of RITA (NSC 652287)Anti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2)…
Product Name: Apogossypolone (ApoG2)Subtitle: Bcl-2 inhibitor,nonpeptidic small moleculeBiological Activity: Biological Activity of Apogossypolone (ApoG2)Description Apogossypolone is a nonpeptidic small-molecule inhibitor of Bcl-2 with Targets Bcl-2 IC50SMLES: CAS NO: 34233-69-7Standard In…
Product Name: SabutoclaxSubtitle: pan-Bcl-2 inhibitorBiological Activity: Biological Activity of SabutoclaxDescription Sabutoclax(BI-97C1) is a inhibitor of Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 values of 0.31 μM, 0.32 μM, 0.20 μM…
Product Name: BM-1074Subtitle: Bcl-2/Bcl-xL inhibitor,potent and selectiveBiological Activity: SMLES: CAS NO: 700874-71-1Standard In CHIKey: DNA-PK inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C50H57ClN8O7S3M.Wt: 1013.68General Tips: For obtaining a higher solubility ,…
Product Name: Obatoclax mesylate (GX15-070)Subtitle: Potent Bcl-2 inhibitorBiological Activity: Biological Activity of Obatoclax mesylate (GX15-070)Obatoclax (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM, can assist in overcoming…