Product Name: RG7112Subtitle: MDM2 inhibitor, first clinicalBiological Activity: Biological Activity of RG7112Description RG7112 is the first clinical small-molecule inhibitor of MDM2. Targets MDM2 IC50SMLES: CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)ClCAS NO: 1403254-99-8Standard In CHIKey: Cell…
Product Name: R1530Subtitle: Antiangiogenesis,mitosis-angiogenesis inhibitor (MAI)Biological Activity: Biological Activity of R1530Multi-kinase inhibitor. Exhibits inhibitory activity against Chk2, KDR, FGFR, Aurora A kinase and Cdk2 (IC50 values are 24, 34, 50,…
Product Name: Pemetrexed disodium hemipenta hydrateSubtitle: Biological Activity: SMLES: C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)NC(CCC(=O)O)C(=O)O.O.CAS NO: 1044870-39-4Standard In CHIKey: LRRK2 inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C20H23N5NaO7+M.Wt: 468.42General Tips: For obtaining a higher solubility ,…
Product Name: p53 and MDM2 proteins-interaction-inhibitor racemicSubtitle: Biological Activity: SMLES: CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CC(=O)N4CCOCC4)(C)C5=CC=C(C=C5)Cl)(C)C6=CC=C(C=C6)ClCAS NO: 182410-00-0Standard In CHIKey: Autophagy inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C40H49Cl2N5O4M.Wt: 734.75General Tips: For obtaining a higher solubility…
Product Name: p53 and MDM2 proteins-interaction-inhibitor chiralSubtitle: P53 and MDM2 proteins-interaction-inhibitorBiological Activity: SMLES: CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CC(=O)N4CCOCC4)(C)C5=CC=C(C=C5)Cl)(C)C6=CC=C(C=C6)ClCAS NO: 1693758-51-8Standard In CHIKey: Autophagy inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C40H49Cl2N5O4M.Wt: 734.75General Tips: For obtaining…
Product Name: Nutlin-3a chiralSubtitle: MDM2 inhibitor, antiproliferative and antiproapoptoticBiological Activity: Biological Activity of Nutlin-3a chiralDescription Nutlin-3 is a small-molecule inhibitor of mouse double minute 2 (MDM2) with IC50 value of…
Product Name: Necrostatin 2Subtitle: In vitro necroptosis inhibitorBiological Activity: Biological Activity of Necrostatin 2Description Necrostatin-2 (Nec-2) is a small molecule inhibitor of RIPK2 kinase activity Targets RIPK2 IC50SMLES: CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3ClCAS NO:…
Product Name: Lenalidomide hydrochlorideSubtitle: TNF-α secretion inhibitorBiological Activity: SMLES: O=C1N(C2C(NC(CC2)=O)=O)CC3=C(N)C=CC=C31.ClCAS NO: 1365888-06-7Standard In CHIKey: Survivin inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C13H14ClN3O3M.Wt: 295.72General Tips: For obtaining a higher solubility ,…
Product Name: LCL161Subtitle: Antagonist of IAPs inhibitorBiological Activity: SMLES: CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NCCAS NO: 1037624-75-1Standard In CHIKey: RIP kinase inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C26H33FN4O3SM.Wt: 500.63General Tips: For obtaining a higher solubility…
Product Name: kb NB 142-70Subtitle: Inhibitor of protein kinase D,selectiveBiological Activity: Biological Activity of kb NB 142-70Selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM…