A given pair of organisms was just the typical exclusive proteins measure for that pair. The unweighted pair group approach with arithmetic imply (UPGMA) was used to create a dendrogram from these distances. The graphical representation of your tree was created making use of Geneious. Additiol file : Full list of random groups. These tables list the random groups made use of for the alysis whose results are summarized in Tables and of your key paper. The column heading NC indicates the order Apocynin number of proteins in that group’s core proteome, even though NU indicates the amount of proteins found inside the proteomes of all members of that group, but no other isolates from the similar genus.Trost et al. BMC Microbiology, : biomedcentral.comPage of. Henz SR, Huson DH, Auch AF, NieseltStruwe K, Schuster SC: Wholegenome prokaryotic phylogeny. Bioinformatics, :. Gogarten JP, Townsend JP: Horizontal gene transfer, genome innovation and evolution. t Rev Microbiol, :. Tettelin H, Masigni V, Cieslewicz MJ, Doti C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones AL, Durkin AS, Deboy RT, Davidsen TM, Mora M, Scarselli M, Margarity Ros I, Peterson JD, Hauser CR, Sundaram JP, Nelson WC, Madupu R, Brinkac LM, Dodson RJ, Rosovitz MJ, Sullivan SA, Daugherty SC, Haft DH, Selengut J, Gwinn ML, Zhou L, Zafar N, Khouri H, Radune D, Dimitrov G, Watkins K, O’Connor KJB, Smith S, Utterback TR, White O, Rubens CE, Grandi G, Madooff LC, Kasper DL, Telford JL, Wessels MR, Rappuoli R, Fraser CM: Genome alysis of various pathogenic isolates of Streptococcus agalactiae: implications for the microbial “pangenome”. Proc tl Acad Sci USA, :. Thompson CC, Vicente ACP, Souza RC, Vasconcelos ATR, Vesth T, Alves N Jr, Ussery DW, Iida T, Thompson FL: Genomic taxonomy of Vibrios. BMC Evol Biol, :. Rasko DA, Rosovitz MJ, MyerSA, Mongodin EF, Fricke WF, Gajer P, Crabtree J, Sebaihia M, Thomson NR, Chaudhuri R, Henderson IR, Sperandio V, Ravel J: The pangenome structure of Escherichia coli: comparative genomic alysis of E. coli commensal and pathogenic isolates. J Bacteriol, :. Medini D, Doti C, Tettelin H, Masigni V, Rappuoli R: The microbial pangenome. Curr Opin Genet Dev, :. Tettelin H, Riley D, Cattuto C, Medini D: Comparative genomics: the bacterial pangenome. Curr Opin Microbiol, :. Altschul 
SF, Gish W, Miller W, Myers EW, Lipman DJ: Fundamental regional alignment search tool. J Mol 
Biol, :. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, PubMed ID:http://jpet.aspetjournals.org/content/125/4/309 Lipman DJ: Gapped BLAST and PSIBLAST: a new generation of protein database search SPDB web programs. Nucleic Acids Res, :. Ljungh A, Wadstrom T: Lactobacillus molecular biology: from genomics to probiotics Caister Academic Press,. Collins MD, Lawson PA, Willems A, Cordoba JJ, FerndezGarayzabal J, Garcia P, Cai J, Hippe H, Farrow JA: The phylogeny in the genus Clostridium: proposal of five new genera and eleven new species combitions. Int J Syst Bacteriol, :. Mdluli K, Slayden RA, Zhu Y, Ramaswamy S, Pan X, Mead D, Crane DD, Musser JM, Barry CE: Inhibition of a Mycobacterium tuberculosis betaketoacyl ACP synthase by isoniazid. Science, :. Kolattukudy PE, Ferndes ND, Azad AK, Fitzmaurice AM, Sirakova TD: Biochemistry and molecular genetics of cellwall lipid biosynthesis in mycobacteria. Mol Microbiol, :. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J.A provided pair of organisms was simply the typical exclusive proteins measure for that pair. The unweighted pair group technique with arithmetic mean (UPGMA) was applied to create a dendrogram from these distances. The graphical representation in the tree was designed employing Geneious. Additiol file : Total list of random groups. These tables list the random groups utilised for the alysis whose results are summarized in Tables and of the major paper. The column heading NC indicates the amount of proteins in that group’s core proteome, though NU indicates the number of proteins located within the proteomes of all members of that group, but no other isolates in the exact same genus.Trost et al. BMC Microbiology, : biomedcentral.comPage of. Henz SR, Huson DH, Auch AF, NieseltStruwe K, Schuster SC: Wholegenome prokaryotic phylogeny. Bioinformatics, :. Gogarten JP, Townsend JP: Horizontal gene transfer, genome innovation and evolution. t Rev Microbiol, :. Tettelin H, Masigni V, Cieslewicz MJ, Doti C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones AL, Durkin AS, Deboy RT, Davidsen TM, Mora M, Scarselli M, Margarity Ros I, Peterson JD, Hauser CR, Sundaram JP, Nelson WC, Madupu R, Brinkac LM, Dodson RJ, Rosovitz MJ, Sullivan SA, Daugherty SC, Haft DH, Selengut J, Gwinn ML, Zhou L, Zafar N, Khouri H, Radune D, Dimitrov G, Watkins K, O’Connor KJB, Smith S, Utterback TR, White O, Rubens CE, Grandi G, Madooff LC, Kasper DL, Telford JL, Wessels MR, Rappuoli R, Fraser CM: Genome alysis of many pathogenic isolates of Streptococcus agalactiae: implications for the microbial “pangenome”. Proc tl Acad Sci USA, :. Thompson CC, Vicente ACP, Souza RC, Vasconcelos ATR, Vesth T, Alves N Jr, Ussery DW, Iida T, Thompson FL: Genomic taxonomy of Vibrios. BMC Evol Biol, :. Rasko DA, Rosovitz MJ, MyerSA, Mongodin EF, Fricke WF, Gajer P, Crabtree J, Sebaihia M, Thomson NR, Chaudhuri R, Henderson IR, Sperandio V, Ravel J: The pangenome structure of Escherichia coli: comparative genomic alysis of E. coli commensal and pathogenic isolates. J Bacteriol, :. Medini D, Doti C, Tettelin H, Masigni V, Rappuoli R: The microbial pangenome. Curr Opin Genet Dev, :. Tettelin H, Riley D, Cattuto C, Medini D: Comparative genomics: the bacterial pangenome. Curr Opin Microbiol, :. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ: Fundamental nearby alignment search tool. J Mol Biol, :. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, PubMed ID:http://jpet.aspetjournals.org/content/125/4/309 Lipman DJ: Gapped BLAST and PSIBLAST: a new generation of protein database search applications. Nucleic Acids Res, :. Ljungh A, Wadstrom T: Lactobacillus molecular biology: from genomics to probiotics Caister Academic Press,. Collins MD, Lawson PA, Willems A, Cordoba JJ, FerndezGarayzabal J, Garcia P, Cai J, Hippe H, Farrow JA: The phylogeny in the genus Clostridium: proposal of 5 new genera and eleven new species combitions. Int J Syst Bacteriol, :. Mdluli K, Slayden RA, Zhu Y, Ramaswamy S, Pan X, Mead D, Crane DD, Musser JM, Barry CE: Inhibition of a Mycobacterium tuberculosis betaketoacyl ACP synthase by isoniazid. Science, :. Kolattukudy PE, Ferndes ND, Azad AK, Fitzmaurice AM, Sirakova TD: Biochemistry and molecular genetics of cellwall lipid biosynthesis in mycobacteria. Mol Microbiol, :. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J.