H, which may have the challenges of bias, lack of data on essential confounding variables and incomplete information and facts from poor documentation. In contrast, the existing study is usually a potential investigation of close to misses occurring inside a tertiary hospital in south western Nigeria. It documents the incidence and traits of close to misses over a a single year period making use of a threelevel conceptual framework (Figure ); the framework was depending on the operate of Reynold and collegues who investigated close to miss materl events in Senegal and is definitely an adaptation from the framework origilly created by McCathy and Maine. The framework facilitated the identification of crucial associated things in the level of patient, socioenvironmental and overall health systems. Our study also examined 
the perital outcomes linked with lifethreatening materl morbidity in Nigeria.MethodsStudy settingThe study, a prospective case control study, was carried out in the Obafemi Awolowo University Teaching Hospitals Complicated (OAUTHC), IleIfe, SouthWestern Nigeria from July to June. OAUTHC can be a multicenter facility that serves as the lead referral center in Osun State and neighbouring Ondo and Ekiti States using a combined population of over ten million. The hospital has two tertiary units Wesley Guild Hospital, Ilesa and Ife Hospital Unit, IleIfe. The study was performed simultaneously in the two tertiaryAdeoye et al. BMC Pregncy and Childbirth, : biomedcentral.comPage ofFigure Conceptual framework for near misses materl morbidity.units; each give emergency obstetric care and have complete complement of materl health and neotal care infrastructures and service providers like obstetricians, TCS 401 anesthesiologists, neotologists, laboratory scientists and nursemidwives. Though the study period was oneyear, there have been periods during which the study 
was interrupted for instance in the course of industrial crises by overall health workers and so on; as such the rate for miss reported in this study was for an interrupted sixmonth period. The study protocol was approved by Ethics and Analysis Committee with the PubMed ID:http://jpet.aspetjournals.org/content/189/1/185 hospital. Informed consent was obtained in the study participants and participation was voluntary.Study population, sample size and selectionThe study population consisted of pregnt ladies who sought care at the hospitals in the course of antetal (third trimester), intrapartum or inside days immediately after delivery. A materl near miss was defined as any lady who seasoned a lifethreatening complication and who nearly died but for the hospital care she received. The operatiol definitions for the close to miss had been according to the diseasespecific criteria described by Filippi et al. which was also utilized by Oladapo et al. within a study on near misses MedChemExpress 3,5,7-Trihydroxyflavone inSagamu, Nigeria. These are (i). Haemorrhage (leading to shock, emergency hysterectomy, coagulation defects, and or blood transfusion of or much more litres of blood); (ii). Hypertensive issues in pregncy eclampsia and extreme preeclampsia with clinical or laboratory indication for termition of pregncy to save the woman’s life (iii). Dystocia uterine rupture and impending rupture e.g. prolonged obstructed labour with preceding caesarian section); (iv). Infection septicaemia from any result in; (v). Extreme aemia: (hemoglobin gdl). For every single near miss case, four unmatched hospital controls were selected inside a defined time limit of hours about the close to miss event. Close to misses events were identified by resident physicians in labour ward as outlined by the abovementioned criteria. The wom.H, which may have the challenges of bias, lack of data on critical confounding variables and incomplete info from poor documentation. In contrast, the present study is often a potential investigation of close to misses occurring in a tertiary hospital in south western Nigeria. It documents the incidence and traits of near misses over a a single year period applying a threelevel conceptual framework (Figure ); the framework was based on the work of Reynold and collegues who investigated close to miss materl events in Senegal and is an adaptation of the framework origilly developed by McCathy and Maine. The framework facilitated the identification of vital related aspects in the level of patient, socioenvironmental and overall health systems. Our study also examined the perital outcomes connected with lifethreatening materl morbidity in Nigeria.MethodsStudy settingThe study, a prospective case manage study, was carried out in the Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), IleIfe, SouthWestern Nigeria from July to June. OAUTHC is actually a multicenter facility that serves because the lead referral center in Osun State and neighbouring Ondo and Ekiti States having a combined population of over ten million. The hospital has two tertiary units Wesley Guild Hospital, Ilesa and Ife Hospital Unit, IleIfe. The study was performed simultaneously at the two tertiaryAdeoye et al. BMC Pregncy and Childbirth, : biomedcentral.comPage ofFigure Conceptual framework for near misses materl morbidity.units; each present emergency obstetric care and have complete complement of materl well being and neotal care infrastructures and service providers like obstetricians, anesthesiologists, neotologists, laboratory scientists and nursemidwives. Although the study period was oneyear, there have been periods throughout which the study was interrupted as an illustration throughout industrial crises by well being workers and so on; as such the rate for miss reported within this study was for an interrupted sixmonth period. The study protocol was approved by Ethics and Investigation Committee on the PubMed ID:http://jpet.aspetjournals.org/content/189/1/185 hospital. Informed consent was obtained in the study participants and participation was voluntary.Study population, sample size and selectionThe study population consisted of pregnt girls who sought care in the hospitals through antetal (third trimester), intrapartum or within days soon after delivery. A materl close to miss was defined as any lady who seasoned a lifethreatening complication and who almost died but for the hospital care she received. The operatiol definitions for the near miss have been determined by the diseasespecific criteria described by Filippi et al. which was also utilized by Oladapo et al. inside a study on close to misses inSagamu, Nigeria. These are (i). Haemorrhage (leading to shock, emergency hysterectomy, coagulation defects, and or blood transfusion of or extra litres of blood); (ii). Hypertensive problems in pregncy eclampsia and serious preeclampsia with clinical or laboratory indication for termition of pregncy to save the woman’s life (iii). Dystocia uterine rupture and impending rupture e.g. prolonged obstructed labour with earlier caesarian section); (iv). Infection septicaemia from any result in; (v). Serious aemia: (hemoglobin gdl). For each near miss case, 4 unmatched hospital controls have been selected within a defined time limit of hours about the near miss occasion. Near misses events have been identified by resident physicians in labour ward according to the abovementioned criteria. The wom.