Product Name: AT-101Subtitle: BH3-mimetic,gossypol enantiomerBiological Activity: Biological Activity of AT-101R-(-)-enantiomer of gossypol. Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces…
Product Name: 3,3-DiindolylmethaneSubtitle: Anticancer and antineoplastic agentBiological Activity: Biological Activity of 3,3-DiindolylmethaneActivator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis;…
Product Name: AT-406 (SM-406)Subtitle: IAP inhibitorBiological Activity: SMLES: CAS NO: 1229705-06-9Standard In CHIKey: Bcl-2 Family inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C32H43N5O4M.Wt: 561.71General Tips: For obtaining a higher solubility ,…
Product Name: ABT-263 (Navitoclax)Subtitle: Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-wBiological Activity: Biological Activity of ABT-263 (Navitoclax)ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with…
Product Name: Nutlin-3bSubtitle: MDM2/p53 inhibitorBiological Activity: Biological Activity of Nutlin-3bDescription Nutlin-3b is an inhibitor of p53-MDM2 interaction with IC50 value of 13.6 µM. Targets p53-MDM2 interaction IC50 13.6 µMSMLES: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)ClCAS…
Product Name: Bendamustine HClSubtitle: Cytostatic agent for non-Hodgkin lymphomasBiological Activity: Biological Activity of Bendamustine HClCytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those…
Product Name: Apoptosis InhibitorSubtitle: Associate with caspase-3 inhibitionBiological Activity: Biological Activity of Apoptosis InhibitorDescription Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction. Targets Caspase IC50SMLES: CAS NO: 23007-85-4Standard In…
Product Name: Caspase-3/7 Inhibitor ISubtitle: Caspase-3/7 inhibitorBiological Activity: Biological Activity of Caspase-3/7 Inhibitor IA potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki =…
Product Name: Z-WEHD-FMKSubtitle: Caspase 5 inhibitor,potent,cell-permeable and irreversibleBiological Activity: Biological Activity of Z-WEHD-FMK A synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity. Targets caspase-5 IC50SMLES: COC(=O)CCC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)OCC4=CC=CC=C4CAS NO: 915087-33-1Standard…
Product Name: Z-VDVAD-FMKSubtitle: Caspase-2 inhibitorBiological Activity: Biological Activity of Z-VDVAD-FMKIrreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells. Targets Caspase-2 IC50SMLES: CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC(=O)OC)NC(=O)C(C(C)C)NC(=O)OCC1=CC=CC=C1CAS NO: 0Standard In CHIKey:…