Lung adenocarcinoma A549 cells and H520 squamous carcinoma cells treated with recombinant human Shh did not show a adjust possibly in cell quantity (Figures 2A and D) or in mobile survival (Figures 2B and E)
Since NSCLC cells can secrete Shh ligand but they do not strongly reply to exogenous Shh, we investigated if Shh could rather activate the adjacent stromal cells. Without a doubt,…