290 (82.six) 50 (82.0) 247 (85.2) (8.0) 43 (four.eight) 0.79(0.38.64) .00 eight (33.6) 233 (66.four) 07 (90.7) 90 (eight.five) (9.3) 43 (eight.five) 2.20 (.09.45) .0.Getting concerned HIV may possibly pose a threat to family members Yes
290 (82.6) 50 (82.0) 247 (85.2) (8.0) 43 (4.8) 0.79(0.38.64) .00 8 (33.six) 233 (66.4) 07 (90.7) 90 (8.5) (9.3) 43 (8.5) two.20 (.09.45) .0.Becoming concerned HIV may perhaps pose a threat to members of the family Yes No 268 (76.eight) 82 (23.2) 229 (85.four) 67 (eight.7) 39 (4.six) five (8.3) .32(0.68.53) .0.Sex with HIVpositive partner in preceding 6 months Yes No 295 (84.0) 56 (six.0) 253 (85.8) 44 (78.6) 42 (4.2) 2 (2.four) .64(0.80.37) .0.Frequency of condom use in earlier 6 months Each time The majority of the time Often Never 236 (80.0) 2 (7.) three (4.four) 25 (8.5) 20 (85.two) 20 (95.two) 2 (92.3) 20 (80.0) 35 (4.8) (four.8) (7.7) five (20.0) .00 three.48(0.456.79) 2.09(0.266.58) 0.70 (0.25.98)0.0.23 0.49 0.50 0.Selfperceived likelihood of contracting HIV from HIVpositive partner Probably Unlikely 09 (three.) 242 (68.9) 0 (92.7) PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/20874419 96 (eight.0) eight (7.three) 46 (9.0) two.96 (.35.52) .Abbreviations: HIV, human immunodeficiency virus; AIDS, acquired immune deficiency syndrome; PrEP, preexposure prophylaxis; CI, self-confidence interval; OR, odds ratio. doi:0.37journal.pone.0067392.tPLOS 1 plosone.orgWillingness to utilize PrEP in HIVDiscordant CouplesTable 4. Partnership in between awareness ofuse ofattitudes toward PrEP and willingness to utilize PrEP.Prepared to work with oral PrEP Variables N Yes, n No, n, OR (95 CI)P value0.Ever heard of vaginal microbicides Yes No Ever heard of PEP Yes No Ever heard of PrEP Yes No 0 (2.8) 34 (97.2) eight (80.0) 289 (84.eight) two (20.0) 52 (5.two) 0.72(0.five.49) .00 34 (9.7) 37 (90.three) 28 (82.4) 269 (84.9) six (7.six) 48 (five.) 0.83 (0.33.2) .00 27 (7.7) 324 (92.three) 26 (96.3) 27 (83.6) (three.7) 53 (6.four) 5.09 (0.688.29) .0.0.Ever taken medicine to stop sexually transmitted disease Yes No 7 (two.0) 344 (98.0) six (85.7) 29 (84.six) (4.three) 53 (5.four) .09 (0.3.26) .0.Worrying about being discriminated against by others because of oral PrEP use Yes No 92 (54.7) 59 (45.three) 45 (75.five) 52 (95.6) 47 (24.5) 7 (4.four) .00 7.04 (three.086.67)0.Abbreviations: PEP, postexposure prophylaxis; PrEP, preexposure prophylaxis; CI, confidence interval; OR, odds ratio. doi:0.37journal.pone.0067392.tWillingness to use oral PrEP and issues related to its useA total of 297 participants (84.6 ) had been willing to work with oral PrEP if proven both effective and safe. The remaining 54 participants (five.four ) have been unwilling to make use of oral PrEP mainly because three (57.four ) believed they were at no risk of contracting HIV, or 28 (five.9 ) had been concerned about its security, or two (22.2 ) doubted its efficacy. Amongst participants prepared to make use of oral PrEP, 258 (86.eight ) have been concerned about its efficacy, 249 (83.8 ) were concerned about its security, 90 (64.0 ) were concerned about its price, and 45 had been concerned about its availability (5.2 ). MedChemExpress GSK2269557 (free base) Relating to social concerns, 3 (38.0 ) participants had no fear of disclosing their use of PrEP to other individuals.Multivariate logistic regression evaluation of aspects linked with willingness to use oral PrEPIn multivariate logistic regression evaluation, willingness to make use of oral PrEP was coded as “”, and unwillingness to work with oral PrEP was coded as “0”. Variables that had been significant (P,0.2) within the univariate analysis had been entered in to the initial multivariate logistic model; these variables included “age”, “ethnicity”, “monthly household income”, “having an excellent awareness of HIVAIDS”, “sex with HIVpositive partner within the previous six months”, “awareness of vaginal microbicides”, “it is hard to avoid HIVAIDS when cohabiting with a HIVpositive partner”, “selfperceived likelihood of contracting HIV from an HIVpositiveAcceptability of oral PrEP in.