Ur individuals just before and immediately after surgery, Table S1: Demographic and pathological data, Table S2: MRI scans and neuropsychological assessments completed by each participant. Author Contributions: Conceptualisation, R.R.-G., M.G.H., G.A.A.B., S.J.P., T.S., Y.E. and J.S.; methodology, software program, validation, formal analysis, R.R.-G., M.G.H., R.A.I.B., A.M., M.A., J.M.G., T.S., Y.E. and J.S.; investigation, sources, R.R.-G., M.G.H., R.A.I.B., A.M., M.A., B.C.-F., J.M.G., G.A.A.B., S.J.P., T.S., Y.E. and J.S.; information curation, R.R.-G., M.G.H. and J.S.; writing assessment and editing, visualisation, R.R.-G., M.G.H., R.A.I.B., A.M., M.A., B.C.-F., J.M.G., G.A.A.B., S.J.P., T.S., Y.E. and J.S.; supervision, project administration, funding acquisition, R.R.-G., M.G.H., T.S., Y.E. and J.S. All authors have study and agreed towards the published version on the manuscript. Funding: This investigation was supported by the Guarantors of Brain, Cancer Research UK Cambridge Centre, The Brain Tumour Charity as well as the EMERGIA Junta de Andalucia system. Y.E. is funded by a Royal Society Dorothy Hodgkin Study Fellowship (DHF130100). JMG is funded by the Ministerio de Ciencia e Innovaci (Espa )/FEDER under the RTI2018-098913-B100 project, by the Consejer de Econom , Innovaci , Ciencia y Empleo (Junta de Andaluc ) and FEDER beneath CV20-45250, A-TIC-080-UGR18, B-TIC-586-UGR20 and P20-00525 projects. MA was funded by a Cambridge Trust–Yousef Jameel Scholarship. This research was also supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). SJP (NIHR Profession Development Fellowship, CDF2018-11-ST2-003) is funded by the National Institute for Wellness Study (NIHR) for this study project. The views expressed are these in the author(s) and not necessarily these on the NIHR or the Division of Overall health and Social Care. Institutional Evaluation Board Statement: The study was carried out based on the guidelines of your Declaration of Helsinki and approved by the Cambridge Central Analysis Ethics Committee (Reference quantity 16/EE/0151). Informed Consent Statement: Informed consent was obtained from all subjects involved in the study. Data Availability Statement: In accordance with ethics requirements, information is going to be made available to collaborating centres upon request. Acknowledgments: The authors thank all sufferers for their generous involvement in the study. We also thank Mallory Owen, Emma Woodberry, Rohitashwa Sinha, Pedro Coelho, Jessica Ingham, Alexa Mcdonald and Luca Villa for their contribution to the study. Conflicts of Interest: The authors report no competing interests.AbbreviationsGS = international signal; BOLD = blood oxygenation level-dependent; MDT = neuro-oncology Deoxythymidine-5′-triphosphate Nucleoside Antimetabolite/Analog multidisciplinary team; FD = framewise displacement; HCs = healthier controls; AMIPB = Adult Memory and Information and facts Processing Battery Task; BIMPB = Brain Injury Rehabilitation Trust Memory and Information and facts Processing Battery; WAIS = Wechsler Adult Intelligence Scale.
cancersArticleTBX2 Drives Neuroendocrine Prostate Cancer through Exosome-Mediated Repression of miR-200c-3pGirijesh Kumar Patel 1 , CYM5442 site Sayanika Dutta 1 , Mosharaf Mahmud Syed 1 , Sabarish Ramachandran 1 , Monica Sharma two , Venkatesh Rajamanickam three , Vadivel Ganapathy 1 , David J. DeGraff four , Kevin Pruitt 2 , Manisha Tripathi 1,five, and Srinivas Nandana 1,five, Division of Cell Biology and Biochemistry, Texas Tech University Overall health Sciences Center, Lubbock, TX 79430, USA; [email protected] (G.K.P.); [email protected] (S.D.