ning the lung and relieving cough, clearing heat and detoxifying, relieving pain and harmonizing medicinal properties. It has contemporary pharmacological effects for instance adrenocorticotropic hormonelike effects, Bradykinin B2 Receptor (B2R) Antagonist web anti-platelet aggregation, anti-peptic ulcer, antipyretic, sedative, and immune enhancing. Qiao et al. (Qiao et al., 2014) analyzed the interaction of far more than 40 chemicalcomponents in Glycyrrhiza glabra L. with cytochrome P450 enzymes and showed that the flavonoids, terpenoids and coumarins in Glycyrrhiza glabra L. had unique degrees of inhibitory effects on the activities of CYP1A2, 2C9, 2C19, 2D6 and 3A4/5, which resulted in slower warfarin metabolism, longer half-life and greater INR. Flavonoids can inhibit platelet function by means of a number of hyperlinks (Xiang et al., 2008), mainly including blocking platelet activating element (PAF) binding to platelet receptors, inhibiting the release of platelet endogenous substances, inhibiting the enhance in intra-platelet Ca2+ and balancing the intra-platelet thromboxane B2-6-ketoprostaglandin (TXB2-6-keto-PGFla) method, which synergistically anticoagulated with warfarin. Curcuma longa L. (Jianghuang): Jianghuang would be the dried CysLT2 Antagonist Species rhizome of Curcuma longa L., household Zingiberaceae. It has the effect of blood circulation activity and discomfort relief. It has contemporary pharmacological effects including antihypertensive, antibacterial, antiviral, hepatoprotective, antioxidant, hypolipidemic and antitumor. Curcuma longa L. promotes the synthesis of prostaglandin PGI2, reduces the production of TXA2, and interferes using the production of cAMP or Ca2+ in platelets. Xia Q et al. discovered that Curcuma longa L. had a powerful inhibitory effect on the CYP3A isoform in the CYP450 enzyme program (Xia et al., 2012). Consequently, Curcuma longa L. in combination with warfarin may possibly improve the anticoagulant effect of warfarin and lead to bleeding; hence, INR values ought to be monitored through clinical remedy. Eleutherococcus senticosus (Rupr. Maxim.) Maxim. (Ciwujia): Eleutherococcus senticosus (Rupr. Maxim.) Maxim. may be the rhizome or stem of Acantha panax senticosus (Rupr. et maxim) Harms, a plant from the genus Wujia, loved ones Wujia. It has the effect of benefiting the qi, strengthening the spleen, tonifying the kidney and calming the mind. It has contemporary pharmacological effects of excitement or inhibition with the central nervous method, antitussive, expectorant and anti-platelet aggregation. Li et al. (2015) showed that Eleutherococcus senticosus (Rupr. Maxim.) Maxim. injection had no substantial effect on APTT, PT and INR in rats, and the Cmax, AUC0-, t1/2, APTT and PT improved when combined with warfarin, suggesting that Eleutherococcus senticosus (Rupr. Maxim.) Maxim. injection itself had no anticoagulant impact, but can affect its pharmacokinetics and anticoagulant impact when combined with warfarin, and weaken warfarin metabolism by inhibiting the effect of CYP2C9 and CYP3A4 (Zeng et al., 2012). Conioselinum anthriscoides `Chuanxiong’ (Chuanxiong): This can be the dried rhizome of Ligusticum chuanxiong Hort of the Umbelliferae family members. It has the impact of activating blood circulation and qi circulation, dispelling wind and relieving pain. Its active ingredient of ligustrazine can dilate coronary arteries, improve coronary blood flow, enhance myocardial blood oxygen provide, and lessen myocardial oxygen consumption; it might lower platelet surface activity, inhibit platelet agglutination, and protect against thrombus formation. Li et al.