ght to investigate whether it induces MUC5AC gene expression and mucin production by airway epithelial cells. Tests have been then performed with NCI-H292 cells (mucoepidermoid lung carcinoma), and also the benefits showed that myristicin substantially inhibited gene expression and production of MUC5AC from NCI-H292 cells. Furthermore, it suppressed the production of mucin protein MUC5AC induced byepidermal growth issue (EGF), even though it did not influence TNF–induced mucin protein MUC5AC production [69]. The pro-sexual effects of myristicin were also investigated. A study performed with an aqueous extract of Piper auritum on Wistar rats showed that, in males with delayed ejaculation, the extract stimulated ejaculatory behavior and recovered the electromyographic activity of the pelvic muscles, participating in seminal emission and ejaculation. By far the most relevant action provoked by the PA was to boost the number of GMPEs (genital motor ULK1 Species ejaculation pattern), hence restoring the ejaculatory capacity. The pro-sexual effects of Piper auritum developed on ejaculatory function are related for the participation of several neurotransmitter systems, and using a prominent part of 5-HT1A serotonin receptors. Even though several other compounds are present in the extract, myristicin includes a pro-serotoninergic action, indicating that it may be responsible for the action shown inside the study [13,70]. An interesting publication discusses the anticonvulsant and inhibitory effects on glial activation of Myristica fragrans (nutmeg) extract. This material, containing about 11 myristicin, was tested in male NMRI rats that had been induced to possess seizures. Behavioral research have shown that pretreatment with nutmeg extract correctly lowered seizure behavior, decreased cell death in the PKD3 Purity & Documentation hypothalamus and enhanced glial activation [71]. Nonetheless with regards to the actions of myristicin around the central nervous technique, a study on the antidepressant prospective of Myristica fragrans was published. Male Wistar rats were submitted to tests for evaluation of antidepressant activity, applying imipramine as a handle and nutmeg extract as a test. Myristicin was not quantified within this extract; nevertheless, because it may be the significant chemical component of seeds, it is probable to correlate its presence with the final results obtained. The extract exhibited an action pretty related to the group treated with imipramine, demonstrating the possible antidepressant activity in the species [72]. Interestingly, the effects of myristicin on appetite were assessed by means of inhalation. In this study, male ddY mice inhaled critical oil of nutmeg and myristicin isolated in the oil. In both instances, there was a rise in appetite and weight gain in mice. Nevertheless, this impact was lost when the compounds have been administered daily to mice (right after 8 days) [73]. A further study sought to assess the anti-obesity effect of nutmeg. The critical oil of Myristica fragrans showed a higher binding activity towards the CB1 cannabinoid receptor. Blocking this receptor reduces appetite and stimulates lipid metabolism, which would cause the antiobesity effect. However, the author relates this activity to a synergism between myristicin along with other compounds found in nutmeg crucial oil [74]. The hepatocarcinogenic effects of myristicin were also evaluated by a study pointed out by Chen et al. (2016). For this, medium white turkey eggs with 22- to 24-day-old fetuses received myristicin injections (25.50 mg/egg), and measurement of DNA strand breaksMolecules 2021, 26,