Name : Rat TNFSF15 Protein
Product Source :
Recombinant Rat TNFSF15 Protein is expressed from HEK293 with His tag at the N-terminus. It contains Thr61-Ile252.[Accession | Q8K3Y7]
Molecular Weight :
The protein has a predicted MW of 22.76 kDa. Due to glycosylation, the protein migrates to 32-40 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Rat TNFSF15 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Rat TNFSF15 is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Rat TNFSF15, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-TNFSF15 Antibody, hFc Tag with the EC50 of 6.4ng/ml determined by ELISA.
Background :
TL1A and its functional receptor DR3 are members of the TNF/TNFR superfamilies of proteins.TL1A and DR3 are abundantly localized at inflamed intestinal areas of patients with IBD and mice with experimental ileitis or colitis and actively participate in the immunological pathways that underlie mucosal homeostasis and intestinal inflammation.Recently, an important role was demonstrated for TL1A/DR3 as potential mediators of intestinal fibrosis that is associated with the presence of gut inflammation.
Synonyms :
TL1A; VEGI-251; TNFSF15; TL1; VEGI; VEGI192A
References & Citations :
(1) Valatas V, Kolios G, Bamias G. TL1A (TNFSF15) and DR3 (TNFRSF25): A Co-stimulatory System of Cytokines With Diverse Functions in Gut Mucosal Immunity. Front Immunol. 2019 Mar 27;10:583. doi: 10.3389/fimmu.2019.00583. PMID: 30972074; PMCID: PMC6445966.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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