Name : Human IL-17Rc Protein
Product Source :
Recombinant Human IL-17Rc Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Leu21-Arg467.[Accession | NP_703190.2]
Molecular Weight :
The protein has a predicted MW of 76.2 kDa. Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human IL-17Rc on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human IL-17Rc is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Human IL-17A, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Human IL-17Rc, hFc Tag with the EC50 of 60.6ng/ml determined by ELISA.
Background :
IL-17RC (interleukin-17 receptor-like) gene codes for a transmembrane protein, the full length of which inhibits apoptosis in prostate cancer cells. IL-17RC gene transcribes over a dozen different splice variants of mRNA. IL-17RC protein isoforms are differentially expressed in prostatic cells and cancer tissues and may play a negative or positive role in the initiation and progression of prostate cancer.
Synonyms :
IL-17 receptor C; IL-17RC; IL17Rhom; IL-17RL; ZcytoR14
References & Citations :
(1) You Z, Dong Y, Kong X, Zhang Y, Vessella RL, Melamed J. Differential expression of IL-17RC isoforms in androgen-dependent and androgen-independent prostate cancers. Neoplasia. 2007 Jun;9(6):464-70. doi: 10.1593/neo.07109. PMID: 17603628; PMCID: PMC1899256.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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