Name : Human IL-20 Protein
Product Source :
Recombinant Human IL-20 Protein is expressed from HEK293 with hFc tag at the N-Terminus. It contains Leu25-Glu176.[Accession | Q9NYY1-1]
Molecular Weight :
The protein has a predicted MW of 44.8 kDa. Due to glycosylation, the protein migrates to 45-50 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human IL-20 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human IL-20 is greater than 95% as determined by SEC-HPLC.
Background :
Interleukin (IL)-20 is a member of the IL-10 family of cytokines, which has been reported to participate in autoimmune inflammatory diseases. However, the potential role of IL-20 in hepatocellular carcinoma (HCC) progression has not yet been investigated. In addition, IL-20 expression was significantly associated with tumor size, metastasis, TNM stage and poor prognosis in patients with HCC.
Synonyms :
IL-20; Cytokine Zcyto10; Zcyto10; IL10D; MGC96907
References & Citations :
(1) Ding WZ, Han GY, Jin HH, Zhan CF, Ji Y, Huang XL. Anti-IL-20 monoclonal antibody suppresses hepatocellular carcinoma progression. Oncol Lett. 2018 Nov;16(5):6156-6162. doi: 10.3892/ol.2018.9402. Epub 2018 Sep 5. PMID: 30333881; PMCID: PMC6176420.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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