Name : Mouse ASGR1 Protein
Product Source :
Recombinant Mouse ASGR1 Protein is expressed from HEK293 with His tag at the N-Terminus. It contains Gln61-Asn284.[Accession | P34927]
Molecular Weight :
The protein has a predicted MW of 26.89 kDa. Due to glycosylation, the protein migrates to 38-55 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse ASGR1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse ASGR1 is greater than 95% as determined by SEC-HPLC.
Background :
ASGR1 is a liver-specific surface marker that is exclusively expressed in liver and mediates internalization and lysosomal degradation of blood asialoglycoproteins.
Synonyms :
ASGP-R 1; ASGPR 1; Hepatic lectin 1; HL-1; mHL-1; Asgr1; Asgr-1;
References & Citations :
Wang JQ, Li LL, Hu A, Deng G, Wei J, Li YF, Liu YB, Lu XY, Qiu ZP, Shi XJ, Zhao X, Luo J, Song BL. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion. Nature. 2022 Aug;608(7922):413-420. doi: 10.1038/s41586-022-05006-3. Epub 2022 Aug 3. PMID: 35922515.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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