Name : Human IL-13Ra1 Protein

Product Source :
Recombinant Human IL-13Ra1 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ala27-Thr343.[Accession | P78552-1]

Molecular Weight :
The protein has a predicted MW of 37.7 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 95% as determined by Tris-Bis PAGE

Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Human IL-13Ra1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SPR Data Human IL-13, His Tag immobilized on CM5 Chip can bind Human IL-13Ra1, His Tag with an affinity constant of 1μM as determined in a SPR assay (Biacore T200).

Background :
Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha, IL-13 R alpha ‘ or NR4, is now referred to as IL-13 R alpha 1. The high-affinity IL-13 binding protein, previously also designated IL-13 R or IL-13 R alpha ‘, is now referred to as IL-13 R alpha 2.

Synonyms :
IL-13 R alpha 1; IL13R; IL13RA; CT19; IL13RA1; NR4; CD213A1; AI882074

References & Citations :
(1) Suzuki A , Leland P , Joshi B H , et al. Targeting of IL-4 and IL-13 receptors for cancer therapy[J]. Cytokine, 2015, 75(1):S1043466615002124.

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