Name : Human IL-1 R9 Protein
Product Source :
Recombinant Human IL-1 R9 Protein is expressed from HEK293 with hFc tag at the C-terminus. It contains Thr17-Lys354.[Accession | Q9NP60]
Molecular Weight :
The protein has a predicted MW of 65.66 kDa. Due to glycosylation, the protein migrates to 75-95 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human IL-1 R9 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human IL-1 R9 is greater than 95% as determined by SEC-HPLC.
Background :
The interleukin 1 receptor (IL-1R) and the Toll-like receptors (TLRs) are highly homologous innate immune receptors that provide the first line of defense against infection. IL-1R have appeared for functions that do not require IL-1 ligand binding is supported by the case of the orphan receptors IL-1R10 and IL-1R9, which do not have known ligands and that have non-immune functions in the brain.
Synonyms :
IL-1-RAPL-2; IL-1RAPL-2; IL1RAPL-2; IL-1R-9; IL-1R9; TIGIRR-1; IL1RAPL2; IL1R9
References & Citations :
(1) González-Navajas JM, Law J, Nguyen KP, Bhargava M, Corr MP, Varki N, Eckmann L, Hoffman HM, Lee J, Raz E. Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. J Exp Med. 2010 Dec 20;207(13):2799-807. doi: 10.1084/jem.20101326. Epub 2010 Nov 29. PMID: 21115691; PMCID: PMC3005235.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
IL-10R alpha Protein
IL-21 Protein
Popular categories:
PTPN22
CD85e/LILRA3