Name : Human Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein
Product Source :
Recombinant Human Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Phe29-Pro1141(ITGA1) acidic tail & Gln21-Asp728(ITGB1) basic tail.[Accession | P56199-1(ITGA1)&P05556-1(ITGB1)]
Molecular Weight :
The protein has a predicted MW of 129.1 kDa(ITGA1)&83.2 kDa(ITGB1). Due to glycosylation, the protein migrates to 160-200 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in 50mM Tris, 150mM NaCl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human ITGA1&ITGB1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Integrin α1β1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen‑binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome.
Synonyms :
Integrin alpha 1 beta 1; alpha 1 beta 1; alpha 1; beta 1; ITGA1&ITGB1; ITGA&ITGB;Integrin alpha 1 β 1; alpha 1 β 1; β 1
References & Citations :
(1). Wang L, Lui VWY. Emerging Roles of ALK in Immunity and Insights for Immunotherapy. Cancers (Basel). 2020 Feb 12;12(2):426. doi: 10.3390/cancers12020426. PMID: 32059449; PMCID: PMC7072244.(2). Gardner H. Integrin α1β1. Adv Exp Med Biol. 2014;819:21-39. doi: 10.1007/978-94-017-9153-3_2. PMID: 25023165.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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