Name : Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer Protein
Product Source :
Recombinant Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Phe24-Gly1012 (ITGA6) acidic tail and GIn21-Asp728 (ITGB1) basic tail.[Accession | P23229-2(ITGA6)&P05556-1(ITGB1)]
Molecular Weight :
The protein has a predicted MW of 117.9 kDa (ITGA6) and 83.2 kDa (ITGB1). Due to glycosylation, the protein migrates to 140-160 kDa (ITGA6) and 110-150 kDa (ITGB1) under Non reducing (N) condition based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human ITGA6&ITGB1 on Tris-Bis PAGE under Non reducing (N) condition. The purity is greater than 95%.
Background :
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling
Synonyms :
α6β1; Integrin alpha 6 beta 1; ITGA6&ITGB1;Integrin alpha 6 β 1
References & Citations :
(1)Wewer U M , Shaw L M , Albrechtsen R , et al. The Integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice[J]. American Journal of Pathology, 1997, 151(5):1191-8.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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