Name : Mouse ITK Protein
Product Source :
Recombinant Mouse ITK Protein is expressed from Baculovirus-Insect Cells with His tag and GST tag at the N-terminus and Strep-II tag at the C-terminus. It contains Arg347-Leu625.[Accession | Q03526]
Molecular Weight :
The protein has a predicted MW of 61.42 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22 μm filtered solution in 50mM Tris, 100mM NaCl, 10% Glycerol, 0.5mM GSH (pH 7.5).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse ITK on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
ITK (IL-2-inducible tyrosine kinase) belongs to the Tec family kinases and is mainly expressed in T cells. It is involved in TCR signalling events driving processes like T cell development as well as Th2, Th9 and Th17 responses thereby controlling the expression of pro-inflammatory cytokines.
Synonyms :
Kinase EMT; Kinase TLK; Emt; Tlk; Tsk; Tcsk
References & Citations :
Lechner KS, Neurath MF, Weigmann B. Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in disease pathogenesis. J Mol Med (Berl). 2020 Oct;98(10):1385-1395. doi: 10.1007/s00109-020-01958-z. Epub 2020 Aug 18. PMID: 32808093; PMCID: PMC7524833.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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