Name : Human Kallikrein 3/PSA Protein
Product Source :
Recombinant Human Kallikrein 3/PSA Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ala18-Pro261.[Accession | P07288-1]
Molecular Weight :
The protein has a predicted MW of 27.93 kDa. Due to glycosylation, the protein migrates to 32-38 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human Kallikrein 3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human Kallikrein 3 is greater than 95% as determined by SEC-HPLC.
Background :
Kallikrein-related peptidase 3 (KLK3), also known as prostate-specific antigen (PSA), is the most useful biomarker for prostate cancer (PCa). KLK3 is suggested to play a role in regulating cancer growth through anti-angiogenic activity in vivo and in vitro.
Synonyms :
PSA; Kallikrein 3; Kallikrein-3; P-30 antigen; Semenogelase; KLK3; APS
References & Citations :
Härkönen HH, Mattsson JM, Määttä JA, Stenman UH, Koistinen H, Matero S, Windshügel B, Poso A, Lahtela-Kakkonen M. The discovery of compounds that stimulate the activity of kallikrein-related peptidase 3 (KLK3). ChemMedChem. 2011 Dec 9;6(12):2170-8. doi: 10.1002/cmdc.201100349. Epub 2011 Sep 27. Erratum in: ChemMedChem. 2011 Dec 9;6(12):2123. PMID: 21953896.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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