Name : Biotinylated Human LAIR2/CD306 Protein
Product Source :
Recombinant Biotinylated Human LAIR2/CD306 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Gln22-Pro152.[Accession | Q6ISS4-1]
Molecular Weight :
The protein has a predicted MW of 17 kDa. Due to glycosylation, the protein migrates to 20-25 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Biotinylated Huma LAIR2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Biotinylated Huma LAIR2 is greater than 95% as determined by SEC-HPLC. SPR Data Biotinylated Human LAIR2, His-Avi Tag immobilized on CM5 Chip can bind Native Human Collagen I, No Tag with an affinity constant of 1.80 nM as determined in SPR assay (Biacore T200).
Background :
The leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) shows increased expression during pregnancy and its reduced expression is associated with pregnancy complications. Although LAIR2 was expressed in the human placenta villus and decidua in the first trimester of pregnancy, it was not expressed in mouse tissues. Knockdown of LAIR2 markedly improved cell viability and inhibited the invasive ability of HTR8/SVneo cells.
Synonyms :
LAIR-2; CD306; LAIR2; MGC71634; XXbac-BCX535A19.6
References & Citations :
(1) Liu, Zhao, Zhou, Huang, Chen, Wang, Hao, Xu, He, Wang (2019) Human-specific LAIR2 contributes to the high invasiveness of human extravillous trophoblast cells Reprod Biol 19(3) 287-292
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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