Name : Human NMNAT1 Protein
Product Source :
Recombinant Human NMNAT1 Protein is expressed from Baculovirus-Insect Cells with His tag at the C-terminus. It contains Met1-Thr279.[Accession | Q9HAN9]
Molecular Weight :
The protein has a predicted MW of 33.46 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in 20mM Tris, 500mM NaCl, 3mM DTT (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human NMNAT1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Nicotinamide mononucleotide adenylyltransferease (NMNAT), a rate-limiting enzyme present in all organisms, reversibly catalyzes the important step in the biosynthesis of NAD from ATP and NMN. NMNAT also catalyzes the metabolic conversion of potent antitumor prodrugs like tiazofurin and benzamide riboside to their active forms which are analogs of NAD.
Synonyms :
NMNAT; LCA9; PNAT1
References & Citations :
Jayaram HN, Kusumanchi P, Yalowitz JA. NMNAT expression and its relation to NAD metabolism. Curr Med Chem. 2011;18(13):1962-72. doi: 10.2174/092986711795590138. PMID: 21517776.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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