Name : Human LILRA1/CD85i/LIR-6 Protein
Product Source :
Recombinant Human LILRA1/CD85i/LIR-6 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Pro17-Asn461.[Accession | O75019-1]
Molecular Weight :
The protein has a predicted MW of 51.4 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human LILRA1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human LILRA1 is greater than 95% as determined by SEC-HPLC.
Background :
LILRA1, also known as CD85i and LIR-6, is an approximately 70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA1 consists of a 445 amino acid (aa) extracellular domain (ECD) with 4 Ig-like domains, a 21 aa transmembrane segment, and a 7 aa cytoplasmic tail. LILRA1 may act as receptor for class I MHC antigens.
Synonyms :
CD85i; LILRA1; LIR6; LIR-6; LIR6MGC126563
References & Citations :
(1)The MHC class I‐LILRB1 signalling axis as a promising target in cancer therapy[J]. Scandinavian Journal of Immunology, 2019.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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