Name : Human LILRB5/CD85c/LIR-8 Protein
Product Source :
Recombinant Human LILRB5/CD85c/LIR-8 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Arg18-His456.[Accession | O75023-1]
Molecular Weight :
The protein has a predicted MW of 49.9 kDa. Due to glycosylation, the protein migrates to 67-72 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human LILRB5 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human LILRB5 is greater than 95% as determined by SEC-HPLC.
Background :
LILRB5, also known as CD85c andLIR-8, belongs to a family of transmembrane glycoproteins that negatively regulate immune cell activation. Mature human LIR-8 consists of a 435 amino acid (aa) extracellular domain with four Ig-like domains, a 21 aa transmembrane segment, and a 111 aa cytoplasmic domain with two immunoreceptor tyrosine-based inhibitory motifs (ITIM). LILRB5 may act as receptor for class I MHC antigens.
Synonyms :
CD85C ; LIR-8; LIR8
References & Citations :
(1)Hogan L E , Jones D C , Allen R L. Expression of the innate immune receptor LILRB5 on monocytes is associated with mycobacteria exposure[J]. Scientific Reports, 2016, 6(1):21780.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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