Name : Mouse LRIG1 Protein
Product Source :
Recombinant Mouse LRIG1 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ala35-Thr794.[Accession | P70193]
Molecular Weight :
The protein has a predicted MW of 84.7 kDa. Due to glycosylation, the protein migrates to 85-110 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 90% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse LRIG1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse LRIG1 is greater than 90% as determined by SEC-HPLC.
Background :
The leucine-rich repeats and immunoglobulin-like domains (LRIG)-1 is a tumor suppressor gene that belongs to the LRIG family. LRIG1 expression has prognostic significance in various human cancers. Somatic mutations, which are associated with a certain rate of response to targeted therapies, are ubiquitously found in human non-small cell lung cancer (NSCLC). LRIG1 was an independent prognostic factor for OS of NSCLC patients. LRIG1 in combination with other clinicopathological risk factors was a stronger prognostic model than clinicopathological risk factors alone.
Synonyms :
LIG-1; LIG1; LRIG1; D6Bwg0781e; Img
References & Citations :
(1) An Y, Zhao Z, Ou P, Wang G. Expression of LRIG1 is Associated With Good Prognosis for Human Non-small Cell Lung Cancer. Medicine (Baltimore). 2015 Nov;94(47):e2081. doi: 10.1097/MD.0000000000002081. PMID: 26632716; PMCID: PMC5058985.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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