Name : Human MFAP5 Protein

Product Source :
Recombinant Human MFAP5 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Ile22-Leu173.[Accession | Q13361-1]

Molecular Weight :
The protein has a predicted MW of 44.1 kDa. Due to furin cleavage and glycosylation, the protein migrates to 32-38 kDa and 55-65 kDa based on Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC

Formulation :
Supplied as 0.22μm filtered solution in PBS (pH 7.4).

Reconstitution :

Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Human MFAP5 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human MFAP5 is greater than 95% as determined by SEC-HPLC.

Background :
Human basal-like breast cancer (BLBC) is an aggressive malignancy with poor prognosis. Since most current treatments are ineffective, there is an urgent need to identify therapeutic targets for BLBC. Microfibrillar-associated protein 5 (MFAP5) plays an important role in the integration of elastic microfibers and the regulation of endothelial cell behaviors.MFAP5 was significantly overexpressed in BLBC tissues and associated with poor metastasis-free survival of patients with BLBC.

Synonyms :
MFAP-5; MAGP-2; MAGP2; MP25; AAT9

References & Citations :
(1) Wu Y, Wu P, Zhang Q, Chen W, Liu X, Zheng W. MFAP5 promotes basal-like breast cancer progression by activating the EMT program. Cell Biosci. 2019 Mar 7;9:24. doi: 10.1186/s13578-019-0284-0. PMID: 30899449; PMCID: PMC6407223.

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