Name : Mouse MFGE-8 Protein
Product Source :
Recombinant Mouse MFGE-8 Protein is expressed from HEK293 with His tag at the N-Terminus. It contains Ala23-Cys463.[Accession | P21956-1]
Molecular Weight :
The protein has a predicted MW of 50.1 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse MFGE-8 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
MFGE8 (Milk Fat Globule EGF And Factor V/VIII Domain Containing) is a Protein Coding gene. Diseases associated with MFGE8 include Anal Paget’s Disease and Topographical Agnosia. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Extracellular vesicle-mediated signaling in recipient cells. This protein plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing.
Synonyms :
Lactadherin; MFGM; MFG-E8; SED1; MP47; BA46; EDIL1; HsT19888; Medin; MFG1; OAcGD3S; SPAG10
References & Citations :
(1) Del Campo M, Galimberti D, Elias N, Boonkamp L, Pijnenburg YA, van Swieten JC, Watts K, Paciotti S, Beccari T, Hu W, Teunissen CE. Novel CSF biomarkers to discriminate FTLD and its pathological subtypes. Ann Clin Transl Neurol. 2018 Sep 7;5(10):1163-1175. doi: 10.1002/acn3.629. PMID: 30349851; PMCID: PMC6186934.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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