Name : Human MMP-2 Protein (pro form)
Product Source :
Recombinant Human MMP-2 Protein is expressed from HEK293 with His tag at the N-Terminus. It contains Ile34-Cys660.[Accession | P08253]
Molecular Weight :
The protein has a predicted MW of 71.6 kDa. Due to glycosylation, the protein migrates to 72-75 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per ug by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22μm filtered solution in 25mM Tris, 150mM NaCl, 50% Glycerol (pH 7.5).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human MMP-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Matrix metalloproteinase (MMP)-2 cleaves a broad spectrum of substrates, including extracellular matrix components (responsible for normal tissue remodeling) and cytokines (modulators of the inflammatory response to physiological insults such as tissue damage). MMP-2 expression is elevated in many cardiovascular pathologies (e.g., myocardial infarction, hypertensive heart disease) where tissue remodeling and inflammatory responses are perturbed.
Synonyms :
Gelatinase A; MMP-2; PEX; CLG4; CLG4A; MONA; TBE-1; MMP-II
References & Citations :
(1) Hardy E, Hardy-Sosa A, Fernandez-Patron C. MMP-2: is too low as bad as too high in the cardiovascular system? Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1332-H1340. doi: 10.1152/ajpheart.00198.2018. Epub 2018 Aug 17. PMID: 30118342.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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