Name : PE-Labeled Human MSLN/Mesothelin Protein
Product Source :
Recombinant PE-Labeled Human MSLN/Mesothelin Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Glu296-Gly580.[Accession | Q13421-2]
Molecular Weight :
The protein has a predicted MW of 35.2 kDa.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
Formulation :
Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 6 months from date of receipt when stored at -80°C.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
ELISA Data Immobilized PE-Labeled Human MSLN, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-MSLN Antibody, hFc Tag with the EC50 of 2.7ng/ml determined by ELISA.
Background :
Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF). Although it has been proposed that mesothelin may be involved in cell adhesion, its biological function is not known.A knockout mouse line that lacks mesothelin reproduces and develops normally.
Synonyms :
MSLN; CAK1; Mesothelin; MPF; MPFSMRP; SMR
References & Citations :
(1)Adusumilli P S , Cherkassky L , Villena-Vargas J , et al. Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity[J]. Science Translational Medicine, 2014, 6(261):261ra151-261ra151.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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