Name : Human NKG2A/CD159a Protein

Product Source :
Recombinant Human NKG2A/CD159a Protein is expressed from HEK293 with His tag and Avi tag at the N-Terminus. It contains Arg100-Leu233.[Accession | P26715-1]

Molecular Weight :
The protein has a predicted MW of 18.3 kDa. Due to glycosylation, the protein migrates to 40-60 kDa based on Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 95% as determined by Tris-Bis PAGE

Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Human NKG2A on Tris-Bis PAGE under reduced condition. The purity is greater than 90%. ELISA Data Immobilized Human NKG2A, His Tag at 2μg/ml (100μl/Well) on the plate. Dose response curve for Anti-NKG2A Antibody, hFc Tag with the EC50 of 5.8ng/ml determined by ELISA (QC Test).

Background :
NKG2, also known as NKG2A(CD159A), is a member of the killer cell lectin-like receptor family. NKG2A marks a unique immune effector subset preferentially co-expressing the tissue-resident CD103 molecule, but not immune checkpoint inhibitors.It is expressed only in NK-cells, but not in T-cells or B-cells.

Synonyms :
NKG2A; NKG2-A; CD94; KLRD1; KP43; KLRC1; CD159A

References & Citations :
(1)Vivier E. Anti-NKG2A mAb is a checkpoint inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells [J]. Cell. Volume 175, Issue 7, 13 December 2018, Pages 1731-1743.e13

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